Sulfobutyl betacyclodextrin is an excellent anionic, highly water-soluble β-CD derivative, which can be well encapsulated with drug molecules to form non-covalent complexes, thus improving drug stability, water solubility, safety, reducing nephrotoxicity, moderating drug haemolysis, controlling drug release rate and masking bad odour. Compared with β-CD, it has better water solubility, less haemolytic effect and lower nephrotoxicity, and is a new type of pharmaceutical excipient with very promising application.

CAS No.: 182410-00-0

Molecular weight: C44H79O33S (2-O-sulfobutyl-β-cyclodextrin); C44H79O33S (6-O-sulfobutyl-β-cyclodextrin); C56H97O33S3 (2,3,6-tri-O-sulfobutyl-β-cyclodextrin)

Molecular weight: 1217; 1217; 1393

Product properties: white powder

Route of administration: Injectable drug, oral drug, nasal drug, eye drug

1. Application in injectables

Role: Solubilizer, stabilizer, improve the solubility and stability of insoluble drugs, so that insoluble drugs can be developed into injectable agents.

Examples: Sulfobutyl betacyclodextrin to improve the solubility of docetaxel, voriconazole, ibuprofen and indomethacin; sulfobutyl betacyclodextrin to improve the stability of carmustine.

2. Application in oral preparations

Role: Solubilizer, stabilizer, enhances bioavailability of insoluble drugs.

Example: Sulfobutyl betacyclodextrin was used to

To improve the bioavailability of flunarizine, danazol, hydrogenated prednisone and prasugrel.

3. Application in ophthalmic preparations

Role: Solubilizer, stabilizer, reduce drug irritation.

Example: Sulfobutyl betacyclodextrin is used to improve the irritation and stability of maurobamate, dipivoxylin, baroxacin and ganciclovir.

4. Application in nasal preparations

Effects: Increase the permeability of the nasal mucosa, improve the solubility and stability of the drug, and improve the metabolic rate of the drug at the target site of administration.

Example: Sulfobutyl betacyclodextrin is used to improve the solubility and stability of midazolam.

5、Ointment softener

Effect: To improve the solubility and stability of the drug.

Example: Sulfobutyl betacyclodextrin is used to improve the solubility and stability of nimesulide.

Packaging and storage.

   Packaging: in accordance with pharmaceutical packaging

   Packing: 1kg/bag; 2kg/bag; 5kg/bag; 10kg/cardboard drum

   Storage: Room temperature, moisture-proof, airtight