Hydroxypropyl betacyclodextrin (HP-β-CD)

Hydroxypropyl betacyclodextrin (HP-β-CD), is a hydroxyalkylated derivative of betacyclodextrin (β-CD). Hydroxypropyl betacyclodextrin is non-toxic and has no side effects. Due to its structural peculiarities, it can greatly improve the solubility of insoluble drugs, and make insoluble or insoluble drugs dissolve in water. Therefore, it can effectively improve the bioavailability of drugs, can greatly improve the quality of drugs and dosage form varieties, widely used in the development and production of new drugs.

Internationally, the nature of hydroxypropyl betacyclodextrin, preparation process, stability, pharmacology, toxicology, teratogenicity, mutagenicity, carcinogenicity, hemolytic effect, and irritation, etc., have made a relatively in-depth study, and its safety has been accurately evaluated. It can be said that at present, it is cyclodextrin derivatives in the study of zui extensive, zui in-depth, zui comprehensive information, in medicine zui valuable pharmaceutical excipients.

The introduction of hydroxypropyl breaks the intramolecular cyclic hydrogen bonding of betacyclodextrin, which overcomes the main disadvantage of poor water solubility of betacyclodextrin while maintaining the cyclodextrin cavity. It is one of the cyclodextrin derivatives with deep research and wide application. Mainly used in food, medicine, cosmetics industry.

1, in the pharmaceutical industry: due to the relative surface activity and hemolytic activity is relatively low and no irritation to the muscle, so hydroxypropyl betacyclodextrin is an ideal injection solubilizer and drug excipient. It can improve the water solubility of insoluble drugs, increase the stability of drugs, improve the bioavailability of drugs, increase the efficacy of pharmaceuticals or reduce the dosage, can adjust or control the release rate of drugs, reduce drug side effects. It can be used for oral drugs, injections, mucosal drug delivery system (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery system, lipophilic targeted drug carriers, and can also be used as protein protectants and stabilizers.

2, in the field of food, spices: hydroxypropyl betacyclodextrin can improve the stability and longevity of nutritional molecules, can mask or correct the bad smell and taste of food nutritional molecules, can improve the production process and product quality. The solubility of the product in water is very good, substitution degree 4 and above can be miscible with water in any proportion, in 50% ethanol and methanol can also be dissolved.

3, in the field of cosmetic raw materials: hydroxypropyl betacyclodextrin used as stabilizers, emulsifiers, deodorants, etc., can reduce the stimulation of organic molecules in cosmetics on the skin and mucous membrane tissues, to enhance the stability of the active ingredient, to prevent volatilization of nutrients, oxidation. It has a certain relative hygroscopicity.